effects of licorice and its bioactive compound on oxidative stress in rat pancreatic islets

Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide

Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide

Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

study on hypericum perforatum and aloe vera effects on function of rat pancreatic islets

Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets

Objective: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level.This study was undertaken to investigateits direct effect on the islets of Langerhans. Material and Methods: Male albino Wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. The islets were incubated for 60 min in Krebs bicarbonate buffer containi...

12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.

High-fat diets lead to obesity, inflammation, and dysglycemia. 12-Lipoxygenase (12-LO) is activated by high-fat diets and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates. We hypothesized that 12-LO in the pancreatic islet is sufficient to cause dysglycemia in the setting of high-fat feeding. To test this, we generated pancreas-specific 12-LO knockout...

improvement in the function of isolated rat pancreatic islets through reduction of oxidative stress using traditional iranian medicine

objective: pancreatic islets have fewer antioxidant enzymes than other tissues and thus are vulnerable to oxidative stress. in the present study, the effects of nine specifically selected iranian medical plants on the mitochondria function and survival of isolated rat islets were examined. materials and methods: in this experimental study, following laparotomy, pancreases of rats were removed a...